mortality/aging
• mutants with 100 CAG repeats exhibit a shorter lifespan than wild-type mice, with an average of 18.7 months
• mutants with 230 CAG repeats have an average lifespan of only 3.5 months
|
growth/size/body
weight loss
(
J:179021
)
• in mutants with 100 and 230 CAG repeats
|
behavior/neurological
• gradual loss of mobility in mutants with 100 and 230 CAG repeats
|
nervous system
• mice exhibit swollen and disoriented Bergmann glia radial processes
|
skeleton
vision/eye
• in mutants with 100 and 230 CAG repeats
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
spinocerebellar ataxia type 7 | DOID:0050958 |
OMIM:164500 |
J:113150 , J:179021 |