Phenotypes Associated with This Genotype

Genotype
MGI:5315852

cn2

• Allelic Composition: Huwe1^tm1Wgu/Y; Tg(Ins2-cre)23Herr/0
• Genetic Background: involves: C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Loss of pancreatic beta-cells in aged Huwe1^tm1Wgu/Y Tg(Ins2-cre)23Herr/0 mice

mortality/aging

premature death ( J:182446 )

♂ • more than half mice died at less than 1 year of age due to severe diabetic symptoms

homeostasis/metabolism

increased circulating glucose level ( J:182446 )

♂ • in fasting and fed mice at 6 and 9 months of age

hyperglycemia ( J:182446 )

♂ • progressive

decreased circulating insulin level ( J:182446 )

♂ • in fasting mice at 9 months

♂ • in fed mice at 6 and 9 months

impaired glucose tolerance ( J:182446 )

♂ • at 3 and 6 months

endocrine/exocrine glands

decreased pancreatic beta cell number ( J:182446 )

♂ • at 6 months and worsening at 9 months

disorganized pancreatic islets ( J:182446 )

♂ • at 6 months and worsening at 9 months, mice exhibit infiltration of alpha cells into the middle of islets unlike in wild-type mice

renal/urinary system

abnormal urinary bladder morphology ( J:182446 )

♂ • enlarged bladder

polyuria ( J:182446 )

♂

growth/size/body

decreased body weight ( J:182446 )

♂ • at 9 months