Phenotypes Associated with This Genotype

Genotype
MGI:5316002

• Allelic Composition: Ezh2^tm2Sho/Ezh2^tm2Sho; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased leukemia incidence ( J:182211 )

• mice treated with pIpC to induce cre expression develop spontaneous T-cell leukemia (T-ALL), with a latency of development of 122-281 days following pIpC treatment

• leukemic cells infiltrate the bone marrow, spleen, liver, and kidney infiltrates comprise a mixture of mature lymphoid cells with open chromatin and cells with blastic appearance and prominent nucleoli

• leukemias are phenotypically heterogenous

immune system

decreased thymocyte number ( J:182211 )

• 7-8 week old mice treated with pIpC to induce cre expression exhibit a 7-10-fold decrease in the numbers of thymocytes

enlarged spleen ( J:182211 )

• mice treated with pIpC to induce cre expression exhibit an enlarged spleen

increased double-negative T cell number ( J:182211 )

• 7-8 week old mice treated with pIpC to induce cre expression exhibit an accumulation of immature CD4-CD8- cell population

decreased double-positive T cell number ( J:182211 )

• 7-8 week old mice treated with pIpC to induce cre expression exhibit a decrease in CD4+CD8+ cells

enlarged lymph nodes ( J:182211 )

• mice treated with pIpC to induce cre expression exhibit enlarged lymph nodes

hematopoietic system

decreased thymocyte number ( J:182211 )

• 7-8 week old mice treated with pIpC to induce cre expression exhibit a 7-10-fold decrease in the numbers of thymocytes

enlarged spleen ( J:182211 )

• mice treated with pIpC to induce cre expression exhibit an enlarged spleen

increased double-negative T cell number ( J:182211 )

• 7-8 week old mice treated with pIpC to induce cre expression exhibit an accumulation of immature CD4-CD8- cell population

decreased double-positive T cell number ( J:182211 )

• 7-8 week old mice treated with pIpC to induce cre expression exhibit a decrease in CD4+CD8+ cells

endocrine/exocrine glands

decreased thymocyte number ( J:182211 )

• 7-8 week old mice treated with pIpC to induce cre expression exhibit a 7-10-fold decrease in the numbers of thymocytes

growth/size/body

enlarged spleen ( J:182211 )

• mice treated with pIpC to induce cre expression exhibit an enlarged spleen

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acute lymphoblastic leukemia		DOID:9952	OMIM:247640 OMIM:613065	J:182211