neoplasm
• mice treated with pIpC to induce cre expression develop spontaneous T-cell leukemia (T-ALL), with a latency of development of 122-281 days following pIpC treatment
• leukemic cells infiltrate the bone marrow, spleen, liver, and kidney infiltrates comprise a mixture of mature lymphoid cells with open chromatin and cells with blastic appearance and prominent nucleoli
• leukemias are phenotypically heterogenous
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immune system
• 7-8 week old mice treated with pIpC to induce cre expression exhibit a 7-10-fold decrease in the numbers of thymocytes
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• mice treated with pIpC to induce cre expression exhibit an enlarged spleen
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• 7-8 week old mice treated with pIpC to induce cre expression exhibit an accumulation of immature CD4-CD8- cell population
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• 7-8 week old mice treated with pIpC to induce cre expression exhibit a decrease in CD4+CD8+ cells
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• mice treated with pIpC to induce cre expression exhibit enlarged lymph nodes
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hematopoietic system
• 7-8 week old mice treated with pIpC to induce cre expression exhibit a 7-10-fold decrease in the numbers of thymocytes
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• mice treated with pIpC to induce cre expression exhibit an enlarged spleen
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• 7-8 week old mice treated with pIpC to induce cre expression exhibit an accumulation of immature CD4-CD8- cell population
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• 7-8 week old mice treated with pIpC to induce cre expression exhibit a decrease in CD4+CD8+ cells
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endocrine/exocrine glands
• 7-8 week old mice treated with pIpC to induce cre expression exhibit a 7-10-fold decrease in the numbers of thymocytes
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growth/size/body
• mice treated with pIpC to induce cre expression exhibit an enlarged spleen
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
acute lymphoblastic leukemia | DOID:9952 |
OMIM:247640 OMIM:613065 |
J:182211 |