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Phenotypes Associated with This Genotype
Genotype
MGI:5316003
Allelic
Composition
Ezh2tm2Sho/Ezh2tm2.1Sho
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129S1/Sv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ezh2tm2.1Sho mutation (0 available); any Ezh2 mutation (72 available)
Ezh2tm2Sho mutation (1 available); any Ezh2 mutation (72 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice treated with pIpC to induce cre expression develop spontaneous T-cell leukemia (T-ALL), with a latency of development of 122-281 days following pIpC treatment
• leukemic cells infiltrate the bone marrow, spleen, liver, and kidney infiltrates comprise a mixture of mature lymphoid cells with open chromatin and cells with blastic appearance and prominent nucleoli
• leukemias are phenotypically heterogenous

immune system
• 7-8 week old mice treated with pIpC to induce cre expression exhibit a 7-10-fold decrease in the numbers of thymocytes
• mice treated with pIpC to induce cre expression exhibit an enlarged spleen
• 7-8 week old mice treated with pIpC to induce cre expression exhibit an accumulation of immature CD4-CD8- cell population
• 7-8 week old mice treated with pIpC to induce cre expression exhibit a decrease in CD4+CD8+ cells
• mice treated with pIpC to induce cre expression exhibit enlarged lymph nodes

hematopoietic system
• 7-8 week old mice treated with pIpC to induce cre expression exhibit a 7-10-fold decrease in the numbers of thymocytes
• mice treated with pIpC to induce cre expression exhibit an enlarged spleen
• 7-8 week old mice treated with pIpC to induce cre expression exhibit an accumulation of immature CD4-CD8- cell population
• 7-8 week old mice treated with pIpC to induce cre expression exhibit a decrease in CD4+CD8+ cells

endocrine/exocrine glands
• 7-8 week old mice treated with pIpC to induce cre expression exhibit a 7-10-fold decrease in the numbers of thymocytes

growth/size/body
• mice treated with pIpC to induce cre expression exhibit an enlarged spleen

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
acute lymphoblastic leukemia DOID:9952 OMIM:247640
OMIM:613065
J:182211


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory