Phenotypes Associated with This Genotype

Genotype
MGI:5316083

cx31

• Allelic Composition: Lepr^db/Lepr^db; Rock1^tm1Leiw/Rock1^tm1Leiw
• Genetic Background: involves: 129S7/SvEvBrd * C57BLKS/J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:182287 )

N • mice treated with streptozotocin to induce diabetes do not exhibit podocyte loss unlike similarly treated Lepr^db homozygotes

increased renal glomerulus apoptosis ( J:182287 )

• mice treated with streptozotocin to induce diabetes exhibit glomerular apoptosis but not as much as in similarly treated Lepr^db homozygotes

enlarged kidney ( J:182287 )

• in mice treated with streptozotocin to induce diabetes as in similarly treated Lepr^db homozygotes

increased kidney weight ( J:182287 )

• in mice treated with streptozotocin to induce diabetes as in similarly treated Lepr^db homozygotes

albuminuria ( J:182287 )

• in mice treated with streptozotocin to induce diabetes but not as much as in similarly treated Lepr^db homozygotes

increased renal glomerulus basement membrane thickness ( J:182287 )

• in mice treated with streptozotocin to induce diabetes but not as much as in similarly treated Lepr^db homozygotes

expanded mesangial matrix ( J:182287 )

• in mice treated with streptozotocin to induce diabetes as in similarly treated Lepr^db homozygotes

homeostasis/metabolism

hyperglycemia ( J:182287 )

• in mice treated with streptozotocin to induce diabetes as in similarly treated Lepr^db homozygotes

albuminuria ( J:182287 )

• in mice treated with streptozotocin to induce diabetes but not as much as in similarly treated Lepr^db homozygotes

growth/size/body

increased body size ( J:182287 )

• in mice treated with streptozotocin to induce diabetes as in similarly treated Lepr^db homozygotes

increased body weight ( J:182287 )

• in mice treated with streptozotocin to induce diabetes as in similarly treated Lepr^db homozygotes

enlarged kidney ( J:182287 )

• in mice treated with streptozotocin to induce diabetes as in similarly treated Lepr^db homozygotes

increased kidney weight ( J:182287 )

• in mice treated with streptozotocin to induce diabetes as in similarly treated Lepr^db homozygotes

cellular

increased renal glomerulus apoptosis ( J:182287 )

• mice treated with streptozotocin to induce diabetes exhibit glomerular apoptosis but not as much as in similarly treated Lepr^db homozygotes

abnormal mitochondrial physiology ( J:182287 )

• mice treated with streptozotocin to induce diabetes exhibit mitochondrial reactive oxygen species production but not as much as in similarly treated Lepr^db homozygotes

• mice treated with streptozotocin to induce diabetes exhibit mitochondrial fission but not as much as in similarly treated Lepr^db homozygotes

oxidative stress ( J:182287 )

• mice treated with streptozotocin to induce diabetes exhibit mitochondrial reactive oxygen species production but not as much as in similarly treated Lepr^db homozygotes