Analysis Tools
cellular
azoospermia
(
J:181650
)
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• no spermatozoa are found in the lumina of the epididymis
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reproductive system
azoospermia
(
J:181650
)
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• no spermatozoa are found in the lumina of the epididymis
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• reduced
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• at 9 and 28 weeks
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• frequently not identifiable
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• frequently not identifiable
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• reduction in the number of mature Leydig cells
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small penis
(
J:181650
)
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• reduced length
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• at 9 and 28 weeks
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small gonad
(
J:181650
)
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• severe hypogonadotropic hypogonadism
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• at 9 and 28 weeks
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small testis
(
J:181650
)
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• at 3, 9 and 28 weeks
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homeostasis/metabolism
| N |
• mice exhibit normal gonadotropin-releasing hormone responsiveness
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• female mice, but not male mice, exhibit a reduction in serum phospholipids compared with wild-type mice
• male and female mice exhibit decreased serum globulin levels compared with wild-type mice
• male and female mice exhibit an increase in the ratio of albumin to globulin compared with wild-type mice
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• in female mice, but not male mice
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• in male mice, but not female mice
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• in male mice
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• basal and Kp-10-stimulated luteinizing hormone levels are reduced in male mice compared to in wild-type mice
• male mice treated with NMDA, RF9 or GALP exhibit less of an increase in luteinizing hormone levels compared with wild-type mice
• following orchiectomy and testosterone treatment, male mice fail to exhibit an increase in luteinizing hormone levels in response to NMDA or RF9 unlike wild-type mice
• male mice treated with senktide fail to exhibit an increase in luteinizing hormone unlike wild-type mice
• following orchiectomy and/or testosterone treatment and withdrawal, mice fail to exhibit a change in luteinizing hormone unlike wild-type mice
• however, mice exhibit normal response to gonadotropin-releasing hormone administration and nor-BNI treatment
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• in female mice, but not male mice
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• in male mice, but not female mice
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• in male mice, but not female mice
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• in male mice, but not female mice
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• in female mice, but not male mice
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• following gonadotropin-releasing hormone administration, mice exhibit a delay in follicle stimulating hormone levels to return to basal levels
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immune system
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• in male mice
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• in male mice
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• in male mice, but not female mice
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• in male mice, but not female mice
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• in male mice, but not female mice
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• in male mice, but not female mice
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hematopoietic system
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• in male mice
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• in male mice
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• in male mice, but not female mice
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• in male mice, but not female mice
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• in male mice, but not female mice
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• in male mice, but not female mice
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• in male mice, but not female mice
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growth/size/body
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• in male mice, but not female mice
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• in male mice
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liver/biliary system
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• in male mice
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renal/urinary system
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• in male and female mice
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small penis
(
J:181650
)
|
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• reduced length
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digestive/alimentary system
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• reduced
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endocrine/exocrine glands
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• modest decrease in adrenal gland weight in female mice
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• in male mice
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• frequently not identifiable
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• frequently not identifiable
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• at 9 and 28 weeks
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• reduction in the number of mature Leydig cells
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small testis
(
J:181650
)
|
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• at 3, 9 and 28 weeks
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| hypogonadotropic hypogonadism 8 with or without anosmia | DOID:0090074 |
OMIM:614837 |
J:181650 | |
