Phenotypes Associated with This Genotype

Genotype
MGI:5316479

• Allelic Composition: Tyr^c-h/Tyr^c-h
• Genetic Background: B6.Cg-Tyr^c-h/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

diluted coat color ( J:178454 )

• the first coat is a uniform light tan

• at the first molt, the body hair becomes lighter, and the ears, nose, tail and scrotum become dark

• mutants treated with nitisinone show increased pigmentation in areas of new hair growth

abnormal iris pigmentation ( J:178454 )

• mutants exhibit iris transillumination that is not observed in wild-type mice

• mutants treated with nitisinone show increased pigmentation in the irides

ocular albinism ( J:178454 )

• eyes are minimally pigmented and appear red

integument

diluted coat color ( J:178454 )

• the first coat is a uniform light tan

• at the first molt, the body hair becomes lighter, and the ears, nose, tail and scrotum become dark

• mutants treated with nitisinone show increased pigmentation in areas of new hair growth

vision/eye

abnormal iris pigmentation ( J:178454 )

• mutants exhibit iris transillumination that is not observed in wild-type mice

• mutants treated with nitisinone show increased pigmentation in the irides

ocular albinism ( J:178454 )

• eyes are minimally pigmented and appear red

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
oculocutaneous albinism		DOID:0050632	OMIM:PS203100	J:178454