Phenotypes Associated with This Genotype

Genotype
MGI:5317846

cx2

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Ccr5^tm1Blck/Ccr5^tm1Blck
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

atherosclerotic lesions ( J:128063 )

• reduced plaque areas after 10-12 weeks on a high fat or high cholesterol diet

• both in the aortic root and the thoracoabdominal artery

• also at 22 weeks when fed a normal diet

immune system

decreased T cell number ( J:128063 )

• in atherosclerotic plaques reduced 24% compared to Apoe^tm1Unc

abnormal mononuclear phagocyte morphology ( J:128063 )

• monocyte/macrophage in atherosclerotic plaques reduced 77% compared to Apoe^tm1Unc

abnormal lymphocyte physiology ( J:128063 )

• reduced proliferative responses of splenocytes and of lymph node cells by 25% compared to Apoe^tm1Unc

abnormal cytokine secretion ( J:128063 )

decreased interferon-gamma secretion ( J:128063 )

• significantly decreased secretion by splenocytes

increased interleukin-10 secretion ( J:128063 )

• increased content in atherosclerotic plaques

• increased secretion by both splenocytes and by lymph node cells

hematopoietic system

decreased T cell number ( J:128063 )

• in atherosclerotic plaques reduced 24% compared to Apoe^tm1Unc

abnormal mononuclear phagocyte morphology ( J:128063 )

• monocyte/macrophage in atherosclerotic plaques reduced 77% compared to Apoe^tm1Unc

abnormal lymphocyte physiology ( J:128063 )

• reduced proliferative responses of splenocytes and of lymph node cells by 25% compared to Apoe^tm1Unc