Phenotypes Associated with This Genotype

Genotype
MGI:5317870

cx16

• Allelic Composition: Tcrb^tm1Mom/Tcrb^tm1Mom; Tg(KRT5-rtTA)1Glk/0; Tg(tetO/CMV-Tslp)#Sfz/0
• Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

skin inflammation ( J:100506 )

• mutants treated with dox for 3 weeks exhibit dermal infiltration mostly of mast cells and eosinophils

abnormal dermal layer morphology ( J:100506 )

• mutants treated with doxycycline (dox) for 3 weeks exhibit dermal infiltration mostly of mast cells and eosinophils

thick epidermis ( J:100506 )

• mutants treated with dox for 3 weeks exhibit epidermal thickening

immune system

decreased IgE level ( J:100506 )

• dox treated mice exhibit little or no serum IgE

skin inflammation ( J:100506 )

• mutants treated with dox for 3 weeks exhibit dermal infiltration mostly of mast cells and eosinophils

hematopoietic system

decreased IgE level ( J:100506 )

• dox treated mice exhibit little or no serum IgE