Phenotypes Associated with This Genotype

Genotype
MGI:5318192

cn1

• Allelic Composition: Erbb4^tm1Grl/Erbb4^tm1Grl; Tg(Myh6-ERBB4)HT2Gass/0
• Genetic Background: B6.Cg-Erbb4^tm1Grl Tg(Myh6-ERBB4)HT2Gass

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:182690 )

N • animals show no alterations in saccharin preference (hedonic behavior) test or resident intruder test (aggression)

impaired contextual conditioning behavior ( J:182690 )

impaired cued conditioning behavior ( J:182690 )

decreased anxiety-related response ( J:182690 )

• mice show lower anxiety than wild-type animals in the elevated-plus maze

increased locomotor activity ( J:182690 )

• animals exhibit significantly more locomotor activity than controls in open field test

nervous system

abnormal long-term potentiation ( J:182690 )

• enhanced LTP in hippocampal slices are resistant to reversal by treatment with recombinant Nrg-1beta protein

enhanced long-term potentiation ( J:182690 )

• significantly enhanced in hippocampal slices (EPSC amplitude 260% vs 180% wild-type)

decreased prepulse inhibition ( J:182690 )

• animals display deficit in PPI; reductions in PPI are more pronounced at lower prepulse sound levels than in controls

• responses are similar to PV-cre/Erbb4^fl mice