Phenotypes Associated with This Genotype

Genotype
MGI:5318339

• Allelic Composition: Dnah11^b2b1203Clo/Dnah11^b2b1203Clo
• Genetic Background: C57BL/6J-Dnah11^b2b1203Clo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Mutant 1203-005-LA exhibits heterotaxy with dextrocardia, inverted lung lobation, inverted liver lobation, and left-sided stomach

growth/size/body

kidney cyst ( J:175213 )

heterotaxia ( J:175213 )

abdominal situs ambiguus ( J:175213 )

situs inversus totalis ( J:175213 )

renal/urinary system

abnormal kidney morphology ( J:175213 )

kidney cyst ( J:175213 )

duplex kidney ( J:175213 )

respiratory system

immotile respiratory cilia ( J:175213 )

• tracheal airway cilia are mostly immotile with some displaying hyperkinetic beat

abnormal respiratory conducting tube morphology ( J:175213 )

cardiovascular system

right aortic arch ( J:175213 )

dual inferior vena cava ( J:175213 )

dextrocardia ( J:175213 )

cellular

immotile respiratory cilia ( J:175213 )

• tracheal airway cilia are mostly immotile with some displaying hyperkinetic beat

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
primary ciliary dyskinesia 7		DOID:0110605	OMIM:611884	J:175213
visceral heterotaxy		DOID:0050545	OMIM:306955 OMIM:605376 OMIM:606325 OMIM:613751 OMIM:614779 OMIM:PS306955	J:175213