reproductive system
infertility
(
J:183239
)
• unable to successfully breed
|
nervous system
• progressive peripheral neuropathy starting at 3-4 weeks of age
|
• at 2 months of age
|
• hypoplastic with a small but significant decrease in length
|
• axon swelling in sciatic nerves
|
• axon degeneration, hypomyelination and axon swelling in sciatic nerves
|
• in sciatic nerves
|
• hypomyelination in sciatic nerves
|
behavior/neurological
• by 3-4 weeks of age
|
• severe locomotor deficiencies
• deficiencies become more severe after 8 months of age
|
• significant increase in the total distance traveled and the number of movement bouts at 5 months of age
|
• significantly less sensitive in a formalin test of spontaneous chemical/inflammatory pain
|
growth/size/body
• at 2 months of age
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
agenesis of the corpus callosum with peripheral neuropathy | DOID:0090003 |
OMIM:218000 |
J:183239 |