Phenotypes Associated with This Genotype

Genotype
MGI:5318772

• Allelic Composition: Slc6a3^tm1Hhg/Slc6a3^tm1Hhg
• Genetic Background: B6.129X1-Slc6a3^tm1Hhg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased locomotor activity ( J:183177 )

• in an open-field test, mutants display higher horizontal activity than controls

nervous system

abnormal CNS synaptic transmission ( J:183177 )

• sensitivity of cannabinoid CB1 receptors (CB1Rs) controlling GABA-mediated synaptic currents in the striatum is lost, however CB1Rs modulating glutamate transmission and GABAB receptors are not affected

abnormal inhibitory postsynaptic currents ( J:183177 )

• the effects of CB1R agonist HU210 on striatal neuron spontaneous inhibitory postsynaptic currents (sIPSCs) and evoked inhibitory postsynaptic currents (eIPSCs) are abolished, indicating loss of sensitivity of CB1Rs(GABA)

• however, the GABAB receptor agonist baclofen has the same effect as in controls

• cocaine or sucrose are unable to alter the HU210 effects on sIPSCs as they do in control mice

abnormal miniature inhibitory postsynaptic current frequency ( J:183177 )

• dihydroxyphenylglycine treatment does not inhibit striatal miniature inhibitory postsynaptic current (mIPSC) frequency as in wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
attention deficit hyperactivity disorder		DOID:1094	OMIM:143465 OMIM:608903 OMIM:608904 OMIM:608905 OMIM:608906 OMIM:612311 OMIM:612312	J:183177