Phenotypes Associated with This Genotype

Genotype
MGI:5318976

• Allelic Composition: Mapt^{tm1(Mecp2)Jae}/Mapt^{tm1(Mecp2)Jae}
• Genetic Background: B6.Cg-Mapt^{tm1(Mecp2)Jae}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:182685 )

nervous system

reduced long-term potentiation ( J:182685 )

• high frequency stimulation-induced long term potentiation is attenuated in hippocampal slices from mutants compared to wild-type mice

abnormal miniature excitatory postsynaptic currents ( J:182685 )

• hippocampal neurons exhibit enhanced miniature excitatory neurotransmission; hippocampal neurons show an increase in mEPSC frequency with no change in mEPSC amplitude

enhanced paired-pulse facilitation ( J:182685 )

• paired-pulse facilitation is augmented in mutants at the interstimulus intervals of 30 and 50 ms

behavior/neurological

abnormal associative learning ( J:182685 )

• mutants display consistent freezing levels across all extinction trials, indicating impaired extinction learning

abnormal contextual conditioning behavior ( J:182685 )

• mutants exhibit an increase in freezing behavior in context (novel environment)-dependent fear conditioning 24 hours after training, suggesting enhanced associative learning

abnormal cued conditioning behavior ( J:182685 )

• mutants exhibit an increase in freezing behavior in cue (auditory tone)-dependent fear conditioning 24 hours after training, suggesting enhanced associative learning

• however, mutants are incapable of extinguishing their conditioned response (freezing) to cue when cue is presented alone (without shock), indicating severe impairments in extinction learning and associative learning

• mutants do not show enhanced freezing behavior in the absence of a paired stimulus (baseline freezing) or before the tone in cued fear conditioning, suggesting that mutants learn to associate the cue with the shock

abnormal object recognition memory ( J:182685 )

• in the NOR task to test ability to recognize a novel object, mutants spend less time with the novel object than wild-type mice and show less preference for the novel object over the familiar indicating impaired episodic memory

increased anxiety-related response ( J:182685 )

• in the elevated plus maze, mutants spend less time in the center, more time in the closed arms, and less time in the open arms compared with wild-type

• in the dark/light test, mutants spend less time in the light side and more time in the dark side, indicating heightened anxiety

impaired coordination ( J:182685 )

• mutants spend less time on the rotarod than wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
syndromic X-linked intellectual disability Lubs type		DOID:0060799	OMIM:300260	J:182685