Phenotypes Associated with This Genotype

Genotype
MGI:5320790

• Allelic Composition: Jak2^tm1Mohi/Jak2⁺; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

enlarged spleen ( J:183821 )

• intermediate in pIpC-treated mice

increased spleen weight ( J:183821 )

• intermediate in pIpC-treated mice

myeloid hyperplasia ( J:183821 )

• increased Gr-1/Mac-1+ cells in the spleen of pIpC-treated mice

abnormal bone marrow cell morphology/development ( J:183821 )

• intermediate increased myeloid, megakaryocyte/erythroid and granulocyte/macrophage progenitors in the bone marrow and spleen of pIpC-treated mice

• increased granulocyte-macrophage progenitors in the spleen of pIpC-treated mice

abnormal common myeloid progenitor cell morphology ( J:183821 )

• increased myeloid progenitors in the spleen of pIpC-treated mice

increased megakaryocyte cell number ( J:183821 )

• in the splenic red pulp of pIpC-treated mice

increased erythroid progenitor cell number ( J:183821 )

• in the splenic red pulp of pIpC-treated mice

• 10-fold increase in CD71/Ter-119+ cells in the spleen of pIpC-treated mice

• intermediate in the bone marrow and spleen of pIpC-treated mice

increased erythrocyte cell number ( J:183821 )

• intermediate in pIpC-treated mice within 4 weeks and sustained for more than 20 weeks

polycythemia ( J:183821 )

• intermediate in pIpC-treated mice

increased hematocrit ( J:183821 )

• in pIpC-treated mice within 4 weeks and sustained for more than 20 weeks

increased hemoglobin content ( J:183821 )

• in pIpC-treated mice within 4 weeks and sustained for more than 20 weeks

microcytosis ( J:183821 )

• in pIpC-treated mice

thrombocytosis ( J:183821 )

• intermediate in pIpC-treated mice

decreased B cell number ( J:183821 )

• in the bone marrow and spleen of pIpC-treated mice

increased leukocyte cell number ( J:183821 )

• intermediate in pIpC-treated mice

increased neutrophil cell number ( J:183821 )

• intermediate in pIpC-treated mice

reticulocytosis ( J:183821 )

• intermediate in pIpC-treated mice

increased hematopoietic stem cell number ( J:183821 )

• in the bone marrow and spleen of pIpC-treated mice

abnormal spleen red pulp morphology ( J:183821 )

• slight reticulin fibrosis in pIpC-treated mice

increased spleen red pulp amount ( J:183821 )

• in pIpC-treated mice with increased number of megakaryocytes and clusters of immature erythroid precursors

abnormal spleen white pulp morphology ( J:183821 )

• fibrosis in pIpC-treated mice

spleen fibrosis ( J:183821 )

• fibrosis in the splenic red and white pulp of pIpC-treated mice

immune system

enlarged spleen ( J:183821 )

• intermediate in pIpC-treated mice

increased spleen weight ( J:183821 )

• intermediate in pIpC-treated mice

myeloid hyperplasia ( J:183821 )

• increased Gr-1/Mac-1+ cells in the spleen of pIpC-treated mice

decreased B cell number ( J:183821 )

• in the bone marrow and spleen of pIpC-treated mice

increased leukocyte cell number ( J:183821 )

• intermediate in pIpC-treated mice

increased neutrophil cell number ( J:183821 )

• intermediate in pIpC-treated mice

abnormal spleen red pulp morphology ( J:183821 )

• slight reticulin fibrosis in pIpC-treated mice

increased spleen red pulp amount ( J:183821 )

• in pIpC-treated mice with increased number of megakaryocytes and clusters of immature erythroid precursors

abnormal spleen white pulp morphology ( J:183821 )

• fibrosis in pIpC-treated mice

spleen fibrosis ( J:183821 )

• fibrosis in the splenic red and white pulp of pIpC-treated mice

skeleton

abnormal bone marrow cavity morphology ( J:183821 )

• mild fibrosis in older pIpC-treated mice

myelofibrosis ( J:183821 )

• fibrosis in the bone marrow cavity of pIpC-treated mice

growth/size/body

enlarged spleen ( J:183821 )

• intermediate in pIpC-treated mice

increased spleen weight ( J:183821 )

• intermediate in pIpC-treated mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
polycythemia vera		DOID:8997	OMIM:263300	J:183821