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Phenotypes Associated with This Genotype
Genotype
MGI:5425229
Allelic
Composition
Zbtb18tm1.1Nda/Zbtb18tm1.1Nda
Tg(Nes-cre)1Kln/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Kln mutation (4 available)
Zbtb18tm1.1Nda mutation (0 available); any Zbtb18 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die at about 3 weeks of age

nervous system
• increased in the neocortex at E16.5, E18.5 and P2
• widespread deficit in neuronal positioning during cortical plate formation
• striking reduction in brain size
• drastic decrease in cortical size
• small and disorganized at P2
• loss of ER81+ layer V, RORb+ layer IV and cux2+ layers II-IV
• layer V-VI neurons are detectable but fail to distribute properly
• progressive thinning beginning at E15.5
• drastic decrease in cortical size
• small and disorganized at P2
• progressive thinning beginning at E15.5
• coherent and persistent expression of neurogenic genes
• increase in gliogenic differentiation
• increase in astrocyte production during early gliogenesis
• general deficit in neuron differentiation
• expression analysis indicates persistence of early precursors

growth/size/body
• visible after 2 weeks of age

cellular
• increased in the neocortex at E16.5, E18.5 and P2
• general deficit in neuron differentiation
• expression analysis indicates persistence of early precursors
• widespread deficit in neuronal positioning during cortical plate formation

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autosomal dominant intellectual developmental disorder DOID:0060307 OMIM:PS156200
J:184434


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory