Phenotypes Associated with This Genotype

Genotype
MGI:5426691

hm1

• Allelic Composition: Oma1^tm1Otin/Oma1^tm1Otin
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased fatty acid beta-oxidation ( J:184716 )

• mice fed standard chow exhibit decreased fatty acid beta-oxidation in brown adipose tissue compared with wild-type mice

• mice fed a high fat diet exhibit decreased fatty acid beta-oxidation in brown adipose tissue and liver compared with wild-type mice

increased susceptibility to diet-induced obesity ( J:184716 )

• at 8 weeks when fed a high fat diet

abnormal blood homeostasis ( J:184716 )

increased circulating leptin level ( J:184716 )

• when fed a high fat diet

increased circulating triglyceride level ( J:184716 )

• when fed a high fat diet

increased circulating alanine transaminase level ( J:184716 )

• when fed a high fat diet

increased circulating aspartate transaminase level ( J:184716 )

• when fed a high fat diet

decreased body temperature ( J:184716 )

• when cold exposed

abnormal circadian temperature homeostasis ( J:184716 )

• mice fed standard chow fail to exhibit an increase in body temperature during the night unlike wild-type mice

abnormal gas homeostasis ( J:184716 )

decreased carbon dioxide production ( J:184716 )

• when fed standard chow

decreased oxygen consumption ( J:184716 )

• when fed standard chow

abnormal glucose homeostasis ( J:184716 )

decreased circulating insulin level ( J:184716 )

• when fed standard chow

impaired glucose tolerance ( J:184716 )

• when fed a high fat diet

increased insulin sensitivity ( J:184716 )

• when fed standard chow but not a high fat diet

decreased basal metabolism ( J:184716 )

• mice fed standard chow exhibit decreased heat production compared with control mice

cellular

abnormal mitochondrial morphology ( J:184716 )

• prior to and after treatment with CCCP, mouse embryonic fibroblasts exhibit alterations in mitochondria morphology with lower fragmentation compared with wild-type cells

abnormal fat cell mitochondrial morphology ( J:184716 )

• mitochondria of brown adipose tissue from cold-exposed mice fed a high fat diet fail to exhibit an increase in mitochondria area unlike wild-type mice

• however, mice do not exhibit a change in the number of mitochondria

decreased mitochondrial DNA content ( J:184716 )

• in mouse embryonic fibroblasts

increased mitochondrial size ( J:184716 )

• in brown adipose tissue of mice fed a high fat diet

abnormal cell physiology ( J:184716 )

• mouse embryonic fibroblasts treated with CCCP, straurosporine or oligomycin exhibit altered OPA1 processing compared with wild-type cells

decreased cellular sensitivity to alkylating agents ( J:184716 )

• in straurosporine treated mouse embryonic fibroblasts

decreased fatty acid beta-oxidation ( J:184716 )

• mice fed standard chow exhibit decreased fatty acid beta-oxidation in brown adipose tissue compared with wild-type mice

• mice fed a high fat diet exhibit decreased fatty acid beta-oxidation in brown adipose tissue and liver compared with wild-type mice

adipose tissue

abnormal fat cell mitochondrial morphology ( J:184716 )

• mitochondria of brown adipose tissue from cold-exposed mice fed a high fat diet fail to exhibit an increase in mitochondria area unlike wild-type mice

• however, mice do not exhibit a change in the number of mitochondria

increased white fat cell size ( J:184716 )

• in gonadal and subcutaneous fat pads when mice are fed a high fat diet

increased gonadal fat pad weight ( J:184716 )

• when fed a high fat diet

abnormal mesenteric fat pad morphology ( J:184716 )

• granuloma-like lesions with necrosis foci in intestinal mesenteric fat when mice are fed a high fat diet

abnormal brown adipose tissue thermogenesis ( J:184716 )

• cold-exposed mice fail to exhibit a decrease in brown adipose tissue droplet size unlike wild-type mice

growth/size/body

increased body weight ( J:184716 )

• when fed standard chow

• at 8 weeks when fed a high fat diet

increased susceptibility to diet-induced obesity ( J:184716 )

• at 8 weeks when fed a high fat diet

liver/biliary system

hepatic steatosis ( J:184716 )

• when fed standard chow or a high fat diet

immune system

granulomatous inflammation ( J:184716 )

• granuloma-like lesions with necrosis foci in intestinal mesenteric fat when mice are fed a high fat diet