Phenotypes for Mir34a Mirc21 Tg(Col1a1-cre)1Kry MGI:5427926 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Mir34a^tm1.1Kry/Mir34a^tm1.1Kry Mirc21^tm1.1Kry/Mirc21^tm1.1Kry Tg(Col1a1-cre)1Kry/0
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir34a^tm1.1Kry mutation (0 available); any Mir34a mutation (10 available)
Mirc21^tm1.1Kry mutation (0 available); any Mirc21 mutation (5 available)
Tg(Col1a1-cre)1Kry mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Increased bone mass in Mir34a^tm1.1Kry/Mir34a^tm1.1Kry Mirc21^tm1.1Kry/Mirc21^tm1.1Kry Tg(Col1a1-cre)1Kry/0 mice

skeleton

skeleton phenotype ( J:185130 )

N	• osteoclast surface is normal

increased osteoblast cell number ( J:185130 )

increased bone mass ( J:185130 )

• at 3 months

abnormal skeleton development ( J:185130 )

• increased bone formation rate

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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