Phenotypes for Fcgr3 Sle21 MGI:5427952 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Fcgr3^tm1Jsv/Fcgr3^tm1Jsv Sle21^129P2/Ola/Sle21^129P2/Ola
Genetic Background	B6.129P2-Fcgr3^tm1Jsv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr3^tm1Jsv mutation (5 available); any Fcgr3 mutation (25 available)
Sle21^129P2/Ola mutation (0 available); any Sle21 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:179175 )

N	• mice exhibit normal mortality

immune system

enlarged spleen ( J:179175 )

increased spleen weight ( J:179175 )

increased B cell number ( J:179175 )

• increased activated B cell

increased activated T cell number ( J:179175 )

increased anti-chromatin antibody level ( J:179175 )

increased anti-double stranded DNA antibody level ( J:179175 )

increased anti-histone antibody level ( J:179175 )

increased anti-single stranded DNA antibody level ( J:179175 )

hematopoietic system

enlarged spleen ( J:179175 )

increased spleen weight ( J:179175 )

increased B cell number ( J:179175 )

• increased activated B cell

increased activated T cell number ( J:179175 )

growth/size/body

enlarged spleen ( J:179175 )

increased spleen weight ( J:179175 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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