Phenotypes Associated with This Genotype

Genotype
MGI:5428133

• Allelic Composition: Nrxn1^tm1Sud/Nrxn1^tm1Sud
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:153748 )

N • mice exhibit no abnormal social behaviors, anxiety-like behaviors, locomotor activity and spatial learning

abnormal motor learning ( J:153748 )

• mice exhibit enhanced motor learning on a rotarod compared with wild-type mice

increased grooming behavior ( J:153748 )

• increased repetitive grooming

abnormal nest building behavior ( J:153748 )

• mice fail to widen nests unlike wild-type mice

• however, nest height is normal

nervous system

abnormal excitatory postsynaptic currents ( J:153748 )

• mice exhibit a decrease in the input-output relationship of excitatory synaptic transmission compared with wild-type mice

abnormal miniature excitatory postsynaptic currents ( J:153748 )

• mice exhibit decreased miniature excitatory postsynaptic current (mEPSC) frequency without a change in miniature inhibitory postsynaptic currents compared with wild-type mice

• however, mEPSC amplitude is normal

decreased prepulse inhibition ( J:153748 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:153748
schizophrenia		DOID:5419	OMIM:181500	J:153748