Analysis Tools
behavior/neurological
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• at 5 months, mice exhibit impaired social recognition memory compared with control mice
• at 12 months, mice lack social recognition memory unlike control mice
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• impaired at 8 months
• amnesia at 12 months
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• at 12 months, mice exhibit impaired object recognition following spatial displacement compared with control mice
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• impaired at 12 months
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• mice exhibit higher swim speeds compared with control mice
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• at 12 months, mice fail to exhibit a decline in activity during the day phase unlike control mice
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• at 5 months mice exhibit increased wake time compared with control mice
• at 5 and 12 months, mice exhibit a decrease in rapid eye movement (REM) sleep compared with control mice
• at 5 months, mice exhibit a reduction in nonREM sleep compared with control mice
• at 12 months mice exhibit longer latency to sleep onset compared with control mice
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nervous system
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N |
• mice do not develop fibrillary plaques or tangles
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• mice exhibit a slowing of electroencephalogram compared with control mice
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• mice exhibit faster decay of long term potentiation compared with control mice
• however, post-tetanic potentiation is normal
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homeostasis/metabolism
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• mice exhibit early and progressive brain glucose metabolism compared with control mice
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Alzheimer's disease | DOID:10652 | J:180977 | ||
