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Phenotypes Associated with This Genotype
Genotype
MGI:5428462
Allelic
Composition
Tg(Sox3)1Pqt/0
Tg(Sox3-EGFP)NrPqt/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• choroid plexus development is normal
• the fourth ventricle is not enlarged
• formation of diencephalic roof plate is inhibited
• thin at E13.5 with fewer elongated cells
• barely discernable at E14.5
• at E15.5, tall columnar cells are only found in the very posterior limits unlike in wild-type cells
• the subcommissural organ (SCO) primordium fails to develop into a functional mature organ unlike in wild-type mice
• however, SCO initiation is normal
• in nearly all mice
• as early as E18.5
• at 3 to 5 weeks
• disorganized at E15.5
• missing at E18.5
• formation of diencephalic roof plate is inhibited
• at E13.5 and E18.5
• at 3 to 5 weeks
• at E13.5 and E18.5

embryo
• formation of diencephalic roof plate is inhibited

craniofacial

cellular
• of subcommissural organ primordium cells at E12.5 without a change in apoptosis

endocrine/exocrine glands
• at E13.5 and E18.5
• thin at E13.5 with fewer elongated cells
• barely discernable at E14.5
• at E15.5, tall columnar cells are only found in the very posterior limits unlike in wild-type cells
• the subcommissural organ (SCO) primordium fails to develop into a functional mature organ unlike in wild-type mice
• however, SCO initiation is normal

skeleton

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hydrocephalus DOID:10908 OMIM:123155
OMIM:236600
OMIM:236635
OMIM:307000
OMIM:615219
J:184232


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory