nervous system
N |
• choroid plexus development is normal
• the fourth ventricle is not enlarged
|
• formation of diencephalic roof plate is inhibited
|
• thin at E13.5 with fewer elongated cells
• barely discernable at E14.5
• at E15.5, tall columnar cells are only found in the very posterior limits unlike in wild-type cells
• the subcommissural organ (SCO) primordium fails to develop into a functional mature organ unlike in wild-type mice
• however, SCO initiation is normal
|
hydrocephaly
(
J:184232
)
• in nearly all mice
|
• as early as E18.5
• at 3 to 5 weeks
|
• disorganized at E15.5
• missing at E18.5
|
• formation of diencephalic roof plate is inhibited
|
• at E13.5 and E18.5
|
• at 3 to 5 weeks
|
• at E13.5 and E18.5
|
embryo
• formation of diencephalic roof plate is inhibited
|
craniofacial
cellular
• of subcommissural organ primordium cells at E12.5 without a change in apoptosis
|
endocrine/exocrine glands
• at E13.5 and E18.5
|
• thin at E13.5 with fewer elongated cells
• barely discernable at E14.5
• at E15.5, tall columnar cells are only found in the very posterior limits unlike in wild-type cells
• the subcommissural organ (SCO) primordium fails to develop into a functional mature organ unlike in wild-type mice
• however, SCO initiation is normal
|
skeleton
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
hydrocephalus | DOID:10908 |
OMIM:123155 OMIM:236600 OMIM:236635 OMIM:307000 OMIM:615219 |
J:184232 |