Phenotypes Associated with This Genotype

Genotype
MGI:5428692

• Allelic Composition: Hprt1^{tm1(Nphs1-CMIP)Dsah}/Hprt1⁺
• Genetic Background: B6.Cg-Hprt1^{tm1(Nphs1-CMIP)Dsah}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

increased mesangial cell number ( J:185411 )

♀ • at 6 months in some glomeruli

increased urine protein level ( J:185411 )

♀

albuminuria ( J:185411 )

♀

abnormal podocyte morphology ( J:185411 )

♀ • flattened and widened

podocyte foot process effacement ( J:185411 )

♀

abnormal podocyte slit diaphragm morphology ( J:185411 )

♀ • narrow in most glomeruli

absent podocyte slit diaphragm ( J:185411 )

♀ • in some areas

expanded mesangial matrix ( J:185411 )

♀ • at 1 year in some glomeruli

glomerulosclerosis ( J:185411 )

♀ • some focal and segmental glomerulosclerosis lesions at 1 year in some glomeruli

homeostasis/metabolism

increased urine protein level ( J:185411 )

♀

albuminuria ( J:185411 )

♀

cellular

increased mesangial cell number ( J:185411 )

♀ • at 6 months in some glomeruli

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
nephrotic syndrome		DOID:1184		J:185411