Phenotypes Associated with This Genotype

Genotype
MGI:5428897

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased cholangiocarcinoma incidence ( J:184949 )

• mutants develop invasive intrahepatic cholangiocarcinoma with low penetrance (1 of 8 mutants) and long latency (at 36 weeks of age)

increased liver tumor incidence ( J:254370 )

• mice develop liver tumors at 12 months of age and do not show obvious symptoms up to 18 months of age

• tumors resemble hepatocellular dysplasia

liver/biliary system

increased cholangiocarcinoma incidence ( J:184949 )

• mutants develop invasive intrahepatic cholangiocarcinoma with low penetrance (1 of 8 mutants) and long latency (at 36 weeks of age)

increased liver tumor incidence ( J:254370 )

• tumors resemble hepatocellular dysplasia

• mice develop liver tumors at 12 months of age and do not show obvious symptoms up to 18 months of age

endocrine/exocrine glands

increased cholangiocarcinoma incidence ( J:184949 )

• mutants develop invasive intrahepatic cholangiocarcinoma with low penetrance (1 of 8 mutants) and long latency (at 36 weeks of age)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
intrahepatic cholangiocarcinoma		DOID:4928		J:184949