Phenotypes Associated with This Genotype

Genotype
MGI:5428914

• Allelic Composition: Tg(Pklr-Myc)73Ak/0
• Genetic Background: involves: C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased hepatocellular carcinoma incidence ( J:185488 )

• mutants fed a carbohydrate-rich diet develop hepatocarcinomas

• frequency of hepatocarcinomas is positively correlated with the carbohydrate content of the diet; frequency increases from 14.3% to 31.7% and 65.2% when the carbohydrate ratio is increased from 10% to 50% to 75%, respectively

increased hepatoma incidence ( J:185488 )

• mutants fed a carbohydrate-rich diet frequently develop hepatomas

endocrine/exocrine glands

pancreatic islet hyperplasia ( J:185488 )

• mutants fed a carbohydrate-rich diet exhibit pancreatic islet hyperplasia, however they do not develop pancreatic tumors

liver/biliary system

increased hepatocellular carcinoma incidence ( J:185488 )

• mutants fed a carbohydrate-rich diet develop hepatocarcinomas

• frequency of hepatocarcinomas is positively correlated with the carbohydrate content of the diet; frequency increases from 14.3% to 31.7% and 65.2% when the carbohydrate ratio is increased from 10% to 50% to 75%, respectively

increased hepatoma incidence ( J:185488 )

• mutants fed a carbohydrate-rich diet frequently develop hepatomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:185488