Phenotypes Associated with This Genotype

Genotype
MGI:5429177

• Allelic Composition: Ruvbl2^M1Btlr/Ruvbl2⁺
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:185495 )

N • mice exhibit a normal response to NP-Ficoll

N • B cell development is normal

increased thymocyte number ( J:185495 )

abnormal class switch recombination ( J:185495 )

• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice

decreased T cell number ( J:185495 )

• T cell deficiency

decreased double-positive T cell number ( J:185495 )

decreased CD4-positive, alpha-beta T cell number ( J:185495 )

• in the spleen

decreased CD8-positive, alpha-beta T cell number ( J:185495 )

• in the spleen

decreased IgG level ( J:185495 )

• response in response to recombinant Semliki Forest virus (SFV) encoded antigen

decreased IgG1 level ( J:185495 )

• 7 days following NP-CGG immunization

• however, levels were normal by day 14

decreased IgM level ( J:185495 )

• 7 days following NP-CGG immunization

• however, levels were normal by day 14

pigmentation

belly spot ( J:185495 )

hematopoietic system

increased thymocyte number ( J:185495 )

abnormal class switch recombination ( J:185495 )

• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice

decreased T cell number ( J:185495 )

• T cell deficiency

decreased double-positive T cell number ( J:185495 )

decreased CD4-positive, alpha-beta T cell number ( J:185495 )

• in the spleen

decreased CD8-positive, alpha-beta T cell number ( J:185495 )

• in the spleen

decreased IgG level ( J:185495 )

• response in response to recombinant Semliki Forest virus (SFV) encoded antigen

decreased IgG1 level ( J:185495 )

• 7 days following NP-CGG immunization

• however, levels were normal by day 14

decreased IgM level ( J:185495 )

• 7 days following NP-CGG immunization

• however, levels were normal by day 14

integument

belly spot ( J:185495 )

endocrine/exocrine glands

increased thymocyte number ( J:185495 )