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Phenotypes Associated with This Genotype
Genotype
MGI:5429215
Allelic
Composition
Ulk4tm1Lex/Ulk4tm1Lex
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ulk4tm1Lex mutation (1 available); any Ulk4 mutation (83 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• majority die before reaching 4 months of age

growth/size/body
• all mutants smaller than control littermates

craniofacial
• domed heads

nervous system
• hemorrhage in lateral and third ventricles
• hemorrhage sometimes accompanied by fibrosis and neovascularization of choroid and meninges
• ependymal cilia are shorter than controls
• marked to severe dilation of lateral ventricles
• hemorrhage sometimes accompanied by fibrosis and neovascularization of choroid and meninges
• marked to severe dilation of third ventricle

immune system
• suppurative otitis media is seen in many animals
• nasal passages partially filled with combinations of proteinaceous fluid or suppurative exudates
• maxillary sinuses partially filled with combinations of proteinaceous fluid or suppurative exudates

respiratory system
• respiratory epithelial cilia are shorter than controls
• nasal passages partially filled with combinations of proteinaceous fluid or suppurative exudates
• maxillary sinuses partially filled with combinations of proteinaceous fluid or suppurative exudates

cellular
• ependymal cilia are shorter than controls
• respiratory epithelial cilia are shorter than controls

cardiovascular system
• hemorrhage in lateral and third ventricles

hearing/vestibular/ear
• suppurative otitis media is seen in many animals

skeleton
• domed heads

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hydrocephalus DOID:10908 OMIM:123155
OMIM:236600
OMIM:236635
OMIM:307000
OMIM:615219
J:185566


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory