mortality/aging
• majority die before reaching 4 months of age
|
growth/size/body
• all mutants smaller than control littermates
|
craniofacial
• domed heads
|
nervous system
• hemorrhage in lateral and third ventricles
|
hydrocephaly
(
J:185566
)
• hemorrhage sometimes accompanied by fibrosis and neovascularization of choroid and meninges
|
• ependymal cilia are shorter than controls
|
• marked to severe dilation of lateral ventricles
|
• hemorrhage sometimes accompanied by fibrosis and neovascularization of choroid and meninges
|
• marked to severe dilation of third ventricle
|
immune system
• suppurative otitis media is seen in many animals
|
• nasal passages partially filled with combinations of proteinaceous fluid or suppurative exudates
|
• maxillary sinuses partially filled with combinations of proteinaceous fluid or suppurative exudates
|
respiratory system
• respiratory epithelial cilia are shorter than controls
|
• nasal passages partially filled with combinations of proteinaceous fluid or suppurative exudates
|
• maxillary sinuses partially filled with combinations of proteinaceous fluid or suppurative exudates
|
cellular
• ependymal cilia are shorter than controls
|
• respiratory epithelial cilia are shorter than controls
|
cardiovascular system
• hemorrhage in lateral and third ventricles
|
hearing/vestibular/ear
• suppurative otitis media is seen in many animals
|
skeleton
• domed heads
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
hydrocephalus | DOID:10908 |
OMIM:123155 OMIM:236600 OMIM:236635 OMIM:307000 OMIM:615219 |
J:185566 |