Phenotypes Associated with This Genotype

Genotype
MGI:5429553

• Allelic Composition: Ak7^{Gt(OST434404)Lex}/Ak7^{Gt(OST434404)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:185566 )

• most mice die before 8 weeks of age

craniofacial

abnormal head shape ( J:185566 )

• domed heads

growth/size/body

growth/size/body region phenotype ( J:185566 )

N • situs inversus not detected in mutant mice

abnormal head shape ( J:185566 )

• domed heads

nervous system

hydrocephaly ( J:185566 )

• moderate to severe hydrocepahlus

reproductive system

oligozoospermia ( J:185566 )

♂ • severe hypospermia

arrest of spermatogenesis ( J:185566 )

♂ • late stage spermatogonic arrest

male infertility ( J:185566 )

♂ • male infertility in rare survivors

respiratory system

rhinosinusitis ( J:185566 )

• chronic active rhinosinusitis with accumulation of proteinaceous and mucopurulent exudates in nasal passages and paranasal sinuses

impaired mucociliary clearance ( J:185566 )

• chronic active rhinosinusitis with accumulation of proteinaceous and mucopurulent exudates in nasal passages and paranasal sinuses

immune system

rhinosinusitis ( J:185566 )

• chronic active rhinosinusitis with accumulation of proteinaceous and mucopurulent exudates in nasal passages and paranasal sinuses

cellular

oligozoospermia ( J:185566 )

♂ • severe hypospermia

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hydrocephalus		DOID:10908	OMIM:123155 OMIM:236600 OMIM:236635 OMIM:307000 OMIM:615219	J:185566