Phenotypes Associated with This Genotype

Genotype
MGI:5429558

• Allelic Composition: Mboat7^tm1Lex/Mboat7^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

cellular phenotype ( J:185566 )

N • normal appearing respiratory and ependymal cilia with no evidence of ciliary dysfunction

craniofacial

abnormal head shape ( J:185566 )

• domed heads

growth/size/body

growth/size/body region phenotype ( J:185566 )

N • situs inversus was not observed

abnormal head shape ( J:185566 )

• domed heads

decreased body size ( J:185566 )

• smaller than controls

mortality/aging

premature death ( J:185566 )

• most die by 1-3 months of age

nervous system

hydrocephaly ( J:185566 )

• moderate to severe hydrocephalus affecting lateral and third ventricles

dilated lateral ventricle ( J:185566 )

dilated third ventricle ( J:185566 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hydrocephalus		DOID:10908	OMIM:123155 OMIM:236600 OMIM:236635 OMIM:307000 OMIM:615219	J:185566