Phenotypes Associated with This Genotype

Genotype
MGI:5429559

• Allelic Composition: Fzd3^tm1(FZD3)Lex/Fzd3^tm1(FZD3)Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired cued conditioning behavior ( J:185566 )

• impaired learning/memory during trace aversive conditioning

decreased depression-related behavior ( J:185566 )

• decreased depressive-like response during tail suspension test

cellular

cellular phenotype ( J:185566 )

N • normal appearing respiratory and ependymal cilia with no evidence of ciliary dysfunction

growth/size/body

growth/size/body region phenotype ( J:185566 )

N • situs inversus was not observed

nervous system

dilated lateral ventricle ( J:185566 )

• varying degrees of dilation of lateral and third ventricles

dilated third ventricle ( J:185566 )

• varying degrees of dilation of lateral and third ventricles

reduced sensorimotor gating ( J:185566 )

• impaired sensorimotor gating

decreased prepulse inhibition ( J:185566 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hydrocephalus		DOID:10908	OMIM:123155 OMIM:236600 OMIM:236635 OMIM:307000 OMIM:615219	J:185566