Phenotypes Associated with This Genotype

Genotype
MGI:5429705

• Allelic Composition: Rag2^tm1.1Cgn/Rag2^tm1.1Cgn; Tg(HLA-DR2)#Lfug/0; Tg(TCROb.1A12)#Lfug/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

autoimmune response ( J:134764 )

• clinical manifestations included both classical and non-classical EAE symptoms

CNS inflammation ( J:134764 )

• focal inflammatory lesions are seen throughout the central nervous system

• inflammatory infiltrate with variable cellular composition, usually containing neutrophilic granulocytes, activated macrophages and T lymphocytes

behavior/neurological

hindlimb paralysis ( J:134764 )

• seen in all mice with an age of onset ranging from 48 to 102 days

nervous system

CNS inflammation ( J:134764 )

• focal inflammatory lesions are seen throughout the central nervous system

• inflammatory infiltrate with variable cellular composition, usually containing neutrophilic granulocytes, activated macrophages and T lymphocytes

demyelination ( J:134764 )

• focal demyelinated tissue lesions are seen throughout the central nervous system, including the optic and vestibular nerves

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
multiple sclerosis		DOID:2377	OMIM:612594 OMIM:612595 OMIM:612596	J:134764