Analysis Tools
endocrine/exocrine glands
 |
• hyperplasia of spindle-like stromal cells
• while aged females develop ovarian cysts, young females display normal steroidogenic and reproductive function
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• cysts show a severe reduction or lack of corpus luteum in aged ovaries, suggesting a cessation of estrous cycling
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• ovarian cysts are characterized by thecal-interstitial hyperplasia
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ovary cyst
(
J:185012
)
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|
• 80% of females develop severe ovarian cysts; cysts increase in size with age
• ovarian cysts show increased steroidogenic capacity as indicated by an increase in the activation of steroidogenic signaling and the presence of lipids in the cells surrounding the cystic lumen
• young females treated with leutinizing hormone alone or with GnRHAnt (to induce cyst formation) show an approximate 3-fold increase in cystic area in the ovaries compared to treated wild-type mice, however hyperinsulinemia is not seen in these mutants
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homeostasis/metabolism
|
• aged females exhibit a 2-fold increase in serum testosterone levels
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reproductive system
|
|
• hyperplasia of spindle-like stromal cells
• while aged females develop ovarian cysts, young females display normal steroidogenic and reproductive function
|
|
|
• cysts show a severe reduction or lack of corpus luteum in aged ovaries, suggesting a cessation of estrous cycling
|
|
|
• ovarian cysts are characterized by thecal-interstitial hyperplasia
|
ovary cyst
(
J:185012
)
|
|
• 80% of females develop severe ovarian cysts; cysts increase in size with age
• ovarian cysts show increased steroidogenic capacity as indicated by an increase in the activation of steroidogenic signaling and the presence of lipids in the cells surrounding the cystic lumen
• young females treated with leutinizing hormone alone or with GnRHAnt (to induce cyst formation) show an approximate 3-fold increase in cystic area in the ovaries compared to treated wild-type mice, however hyperinsulinemia is not seen in these mutants
|
growth/size/body
ovary cyst
(
J:185012
)
|
|
• 80% of females develop severe ovarian cysts; cysts increase in size with age
• ovarian cysts show increased steroidogenic capacity as indicated by an increase in the activation of steroidogenic signaling and the presence of lipids in the cells surrounding the cystic lumen
• young females treated with leutinizing hormone alone or with GnRHAnt (to induce cyst formation) show an approximate 3-fold increase in cystic area in the ovaries compared to treated wild-type mice, however hyperinsulinemia is not seen in these mutants
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| polycystic ovary syndrome | DOID:11612 |
OMIM:184700 |
J:185012 | |
