Phenotypes for Tg(Prrx1-FUS/DDIT3)1Mete Trp53 MGI:5430234 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Trp53^tm1Tyj/Trp53^tm1Tyj Tg(Prrx1-FUS/DDIT3)1Mete/0
Genetic Background	involves: 129S2/SvPas * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Prrx1-FUS/DDIT3)1Mete mutation (1 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased sarcoma incidence ( J:184491 )

• predominantly in the appendicular skeleton

increased liposarcoma incidence ( J:184491 )

• mice develop myxoid round cell liposarcoma

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
myxoid liposarcoma		DOID:5363	OMIM:613488	J:184491

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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