Phenotypes Associated with This Genotype

Genotype
MGI:5430588

cn2

• Allelic Composition: Apc^tm2.1Cip/Apc^tm2.1Cip; Tg(Ttr-cre/Esr1*)1Vco/0
• Genetic Background: B6.Cg-Apc^tm2.1Cip Tg(Ttr-cre/Esr1*)1Vco

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased NK T cell number ( J:184496 )

• tamoxifen-treated mutants exhibit a decrease (14.9% vs. 28.6% in controls) of invariant NKT (iNKT) cells in the entire population of immune cells; the diminished proportion of iNKTs is more pronounced in the CD4+ iNKT cells than in the CD4- iNKT cells

abnormal NK T cell physiology ( J:184496 )

• iNKT activation level is higher in the liver of tamoxifen-treated mutants than in controls

immune system

decreased NK T cell number ( J:184496 )

• tamoxifen-treated mutants exhibit a decrease (14.9% vs. 28.6% in controls) of invariant NKT (iNKT) cells in the entire population of immune cells; the diminished proportion of iNKTs is more pronounced in the CD4+ iNKT cells than in the CD4- iNKT cells

abnormal NK T cell physiology ( J:184496 )

• iNKT activation level is higher in the liver of tamoxifen-treated mutants than in controls

increased interferon-gamma secretion ( J:184496 )

• CD4+ and CD4- subpopulations of iNKTs isolated from mutant livers produce higher amounts of IFN-gamma compared to controls

increased interleukin-4 secretion ( J:184496 )

• CD4+ and CD4- subpopulations of iNKTs isolated from mutant livers produce higher amounts of IL-4 compared to controls

liver inflammation ( J:184496 )

• tamoxifen-treated mutants exhibit higher absolute numbers of most types of immune cells in the liver, including Kupffer cells, granulocytes, NK, B lymphocytes, and conventional T cells

• mutant livers are more sensitive to ConA-induced hepatitis than controls

liver/biliary system

liver inflammation ( J:184496 )

• tamoxifen-treated mutants exhibit higher absolute numbers of most types of immune cells in the liver, including Kupffer cells, granulocytes, NK, B lymphocytes, and conventional T cells

• mutant livers are more sensitive to ConA-induced hepatitis than controls

abnormal liver morphology ( J:184496 )

• mutants injected with tamoxifen exhibit significantly higher total numbers of nonparenchymal cells (NPCs) in the liver

enlarged liver ( J:184496 )

• mutants injected with tamoxifen develop progressive hepatomegaly

growth/size/body

enlarged liver ( J:184496 )

• mutants injected with tamoxifen develop progressive hepatomegaly