Phenotypes for Apc Lect2 Tg(Ttr-cre/Esr1*)1Vco MGI:5430589 MGI Mouse

premature death ( J:184496 )

• tamoxifen treated mutants exhibit a decrease in survival rate

increased hepatocyte apoptosis ( J:184496 )

• increase in liver apoptosis in tamoxifen treated mutants

• liver inflammation is increased in tamoxifen treated mutants compared to single Apc mutants

• livers of tamoxifen treated mutants exhibit a flaccid and loose texture compared to livers from single Apc homozygotes

• mutants injected with tamoxifen exhibit significantly higher total numbers of nonparenchymal cells (NPCs) in the liver

hepatic necrosis ( J:184496 )

• in tamoxifen treated mutants

increased NK T cell number ( J:184496 )

• number of iNKT cells in the liver is increased in tamoxifen-treated double mutants compared to single Apc mutants

abnormal neutrophil physiology ( J:184496 )

• liver infiltrating immune cells of tamoxifen treated mutants have an increase in neutrophils compared to infiltrating immune cells in single Apc mutants

abnormal NK T cell physiology ( J:184496 )

• invariant NKTs (iNKTs) are more activated in tamoxifen treated double mutant livers than in single Apc mutant livers

abnormal chemokine level ( J:184496 )

• chemokines in the liver of tamoxifen treated mutants, such as Cxcl1, Cxcl12, and Cxcl12 are induced to higher levels in double mutants than in single Apc mutants

decreased interferon-gamma secretion ( J:184496 )

• CD4- iNKTs from tamoxifen treated mutants produce less IFN-gamma than CD4- iNKTs of single Apc mutants

increased interleukin-4 secretion ( J:184496 )

• CD4- iNKTs from tamoxifen treated mutants produce more IL-4 than CD4- iNKTs of single Apc mutants

liver inflammation ( J:184496 )