Phenotypes Associated with This Genotype

Genotype
MGI:5430590

• Allelic Composition: Lect2^tm1Ymg/Lect2^tm1Ymg; Tg(Pklr-Myc)73Ak/0
• Genetic Background: B6.Cg-Lect2^tm1Ymg Tg(Pklr-Myc)73Ak

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased malignant tumor incidence ( J:184496 )

• tumors have higher grades of malignancy and are less differentiated than those of single Tg(Pklr-Myc)73Ak mice

increased hepatocellular carcinoma incidence ( J:184496 )

• mutants develop hepatocellular carcinoma

• the number and size of tumor nodules in double mutants is greater than in single Tg(Pklr-Myc)73Ak mice

• some tumors in double mutants exhibit a very poorly differentiated phenotype (fetal-like phenotype) that is never seen in tumors of single Tg(Pklr-Myc)73Ak mice

• tumors have higher mitotic indices compared with tumors from single Tg(Pklr-Myc)73Ak mice

liver/biliary system

increased hepatocellular carcinoma incidence ( J:184496 )

• mutants develop hepatocellular carcinoma

• the number and size of tumor nodules in double mutants is greater than in single Tg(Pklr-Myc)73Ak mice

• some tumors in double mutants exhibit a very poorly differentiated phenotype (fetal-like phenotype) that is never seen in tumors of single Tg(Pklr-Myc)73Ak mice

• tumors have higher mitotic indices compared with tumors from single Tg(Pklr-Myc)73Ak mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:184496