Phenotypes Associated with This Genotype

Genotype
MGI:5430591

• Allelic Composition: Tcra-J^tm1Tgi/Tcra-J^tm1Tgi; Tg(Pklr-Myc)73Ak/0
• Genetic Background: B6.Cg-Tcra-J^tm1Tgi Tg(Pklr-Myc)73Ak

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased metastatic potential ( J:184496 )

• 40% of double mutants exhibit lung metastasis which is not seen in single Tg(Pklr-Myc)73Ak mice

increased malignant tumor incidence ( J:184496 )

• tumors have higher grades of malignancy and are less differentiated than those of single Tg(Pklr-Myc)73Ak mice

increased hepatocellular carcinoma incidence ( J:184496 )

• mutants develop hepatocellular carcinoma (HCC); stronger promotion of initiation and progression steps of HCC development compared to single Tg(Pklr-Myc)73Ak mice

• the number and size of tumor nodules in double mutants is greater than in single Tg(Pklr-Myc)73Ak mice

• some tumors in double mutants exhibit a very poorly differentiated phenotype (fetal-like phenotype) that is never seen in tumors of single Tg(Pklr-Myc)73Ak mice

• tumors have higher mitotic indices compared with tumors from single Tg(Pklr-Myc)73Ak mice

liver/biliary system

increased hepatocellular carcinoma incidence ( J:184496 )

• mutants develop hepatocellular carcinoma (HCC); stronger promotion of initiation and progression steps of HCC development compared to single Tg(Pklr-Myc)73Ak mice

• the number and size of tumor nodules in double mutants is greater than in single Tg(Pklr-Myc)73Ak mice

• some tumors in double mutants exhibit a very poorly differentiated phenotype (fetal-like phenotype) that is never seen in tumors of single Tg(Pklr-Myc)73Ak mice

• tumors have higher mitotic indices compared with tumors from single Tg(Pklr-Myc)73Ak mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:184496