Phenotypes for Inpp5b Ocrl Tg(INPP5B)CNbm MGI:5430751 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Inpp5b^tm1Nbm/Inpp5b^tm1Nbm Ocrl^tm1Nbm/Ocrl^tm1Nbm Tg(INPP5B)CNbm/0
Genetic Background	involves: 129S/SvEv * 129S6/SvEvTac * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Inpp5b^tm1Nbm mutation (0 available); any Inpp5b mutation (57 available)
Ocrl^tm1Nbm mutation (1 available); any Ocrl mutation (9 available)
Tg(INPP5B)CNbm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:185879 )

• a few mice die by 6 weeks of age

growth/size/body

decreased birth body size ( J:185879 )

• in a few mice

decreased body weight ( J:185879 )

postnatal growth retardation ( J:185879 )

• by 4 weeks

renal/urinary system

aminoaciduria ( J:185879 )

increased urine microglobulin level ( J:185879 )

vision/eye

vision/eye phenotype ( J:185879 )

N	• mice exhibit normal lens development and do not develop cataracts

homeostasis/metabolism

aminoaciduria ( J:185879 )

increased urine microglobulin level ( J:185879 )

Mouse Models of Human Disease	DO ID	OMIM ID(s)	Ref(s)
Dent disease	DOID:0050699	OMIM:300009 OMIM:300555	J:185879
oculocerebrorenal syndrome	DOID:1056	OMIM:309000	J:185879

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24