Phenotypes for Inpp5b Ocrl Tg(INPP5B)CNbm MGI:5430752 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Inpp5b^tm1Nbm/Inpp5b^tm1Nbm Ocrl^tm1Nbm/Y Tg(INPP5B)CNbm/0
Genetic Background	involves: 129S/SvEv * 129S6/SvEvTac * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Inpp5b^tm1Nbm mutation (0 available); any Inpp5b mutation (57 available)
Ocrl^tm1Nbm mutation (1 available); any Ocrl mutation (9 available)
Tg(INPP5B)CNbm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:185879 )

• a few mice die by 6 weeks of age

growth/size/body

decreased birth body size ( J:185879 )

• in a few mice

decreased body weight ( J:185879 )

postnatal growth retardation ( J:185879 )

• by 4 weeks

renal/urinary system

aminoaciduria ( J:185879 )

increased urine microglobulin level ( J:185879 )

vision/eye

vision/eye phenotype ( J:185879 )

N	• mice exhibit normal lens development and do not develop cataracts

homeostasis/metabolism

aminoaciduria ( J:185879 )

increased urine microglobulin level ( J:185879 )

Mouse Models of Human Disease	DO ID	OMIM ID(s)	Ref(s)
Dent disease	DOID:0050699	OMIM:300009 OMIM:300555	J:185879
oculocerebrorenal syndrome	DOID:1056	OMIM:309000	J:185879

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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