Phenotypes Associated with This Genotype

Genotype
MGI:5431138

• Allelic Composition: Gt(ROSA)26Sor^{tm1(tTA,tetO-Mir155)Fjsl}/Gt(ROSA)26Sor⁺; Tg(Nes-cre)1Wmz/0
• Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Gt(ROSA)26Sor^{tm1(tTA,tetO-Mir155)Fjsl}/Gt(ROSA)26Sor⁺ Tg(Nes-cre)1Wmz/0 mice develop disseminated lymphoma

growth/size/body

enlarged liver ( J:185598 )

• in some mice reared without doxycycline

enlarged spleen ( J:185598 )

• by 5 months in mice reared without doxycycline

increased spleen weight ( J:185598 )

• 10 times in mice reared without doxycycline

mortality/aging

premature death ( J:185598 )

• mice reared without doxycycline die between 3 and 5 months

• however, doxycycline treatment rescues phenotype

immune system

abnormal immune system morphology ( J:185598 )

• mice reared without doxycycline develop lymphoid pathology as early as 2 weeks of age

thymus hyperplasia ( J:185598 )

• in mice reared without doxycycline

enlarged spleen ( J:185598 )

• by 5 months in mice reared without doxycycline

increased spleen weight ( J:185598 )

• 10 times in mice reared without doxycycline

increased spleen white pulp amount ( J:185598 )

• in mice reared without doxycycline

enlarged lymph nodes ( J:185598 )

• by 5 months in mice reared without doxycycline

behavior/neurological

ataxia ( J:185598 )

• occasionally in mice reared without doxycycline

hunched posture ( J:185598 )

• in mice reared without doxycycline

• however, doxycycline treatment rescues phenotype

hindlimb paresis ( J:185598 )

• severe hind limb paresis in some mice reared without doxycycline

• however, doxycycline treatment rescues phenotype

neoplasm

tumor regression ( J:185598 )

• following treatment with doxycycline partially due to apoptosis in mice reared without doxycycline

increased B cell derived lymphoma incidence ( J:185598 )

• in most mice reared without doxycycline

• however, doxycycline treatment rescues phenotype

integument

abnormal coat appearance ( J:185598 )

• scruffy in mice reared without doxycycline

• however, doxycycline treatment rescues phenotype

liver/biliary system

enlarged liver ( J:185598 )

• in some mice reared without doxycycline

nervous system

nervous system phenotype ( J:185598 )

N • doxycycline-treated mice exhibit normal brain morphology

respiratory system

respiratory distress ( J:185598 )

• by 5 months in mice reared without doxycycline

• however, doxycycline treatment rescues phenotype

cellular

increased apoptosis ( J:185598 )

• tumor cells from mice reared without doxycycline exhibit increased apoptosis following doxycycline treatment

hematopoietic system

thymus hyperplasia ( J:185598 )

• in mice reared without doxycycline

enlarged spleen ( J:185598 )

• by 5 months in mice reared without doxycycline

increased spleen weight ( J:185598 )

• 10 times in mice reared without doxycycline

increased spleen white pulp amount ( J:185598 )

• in mice reared without doxycycline

endocrine/exocrine glands

thymus hyperplasia ( J:185598 )

• in mice reared without doxycycline

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lymphoma		DOID:0060058		J:185598