Phenotypes Associated with This Genotype

Genotype
MGI:5431967

• Allelic Composition: Tg(RIR-Tag)87Dh/0
• Genetic Background: involves: C57BL/6J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:50695 )

• mutants die at 9-12 weeks of age; almost complete penetrance

• mutants placed on a high sugar diet to counteract hypoglycemia liver longer

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:50695 )

• hyperplasia of the islets of Langerhans

• organization of alpha and delta cells is disrupted in islets

decreased pancreatic alpha cell number ( J:50695 )

• reduced numbers of alpha cells in islets

increased pancreatic beta cell number ( J:50695 )

• islets are densely packed with beta-cells

decreased pancreatic delta cell number ( J:50695 )

• reduced numbers of delta cells in islets

increased pancreas tumor incidence ( J:50695 )

• mutants placed on a high sugar diet to counteract hypoglycemia develop solid pancreatic tumors between 10 and 20 weeks of age; tumors are pure beta-cell tumors

• no evidence that tumors metastasize other organs

neoplasm

increased pancreas tumor incidence ( J:50695 )

• mutants placed on a high sugar diet to counteract hypoglycemia develop solid pancreatic tumors between 10 and 20 weeks of age; tumors are pure beta-cell tumors

• no evidence that tumors metastasize other organs

homeostasis/metabolism

hypoglycemia ( J:50695 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic carcinoma		DOID:4905	OMIM:260350	J:50695