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Phenotypes Associated with This Genotype
Genotype
MGI:5431978
Allelic
Composition
Ptentm1Rdp/Ptentm1Rdp
Terttm3Rdp/Terttm3Rdp
Trp53tm1Brn/Trp53tm1Brn
Tg(Pbsn-cre)4Prb/0
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Rdp mutation (0 available); any Pten mutation (88 available)
Terttm3Rdp mutation (0 available); any Tert mutation (55 available)
Tg(Pbsn-cre)4Prb mutation (2 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (240 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• develop bulky lethal tumors by age 24 weeks of age

endocrine/exocrine glands
• at generations 3 and 4 (G3/4), all develop invasive prostate adenocarcinomas by 24 weeks of age
• at G3/4, high-grade prostate intraepithelial neoplasia (HPIN) in all mice by 9 weeks of age

neoplasm
• at generations 3 and 4 (G3/4), all develop invasive prostate adenocarcinomas by 24 weeks of age
• at G3/4, high-grade prostate intraepithelial neoplasia (HPIN) in all mice by 9 weeks of age
• in some (5 of 20) G3/4 mice lumbar spine metastases are seen unlike in G0 mice

reproductive system
• at generations 3 and 4 (G3/4), all develop invasive prostate adenocarcinomas by 24 weeks of age
• at G3/4, high-grade prostate intraepithelial neoplasia (HPIN) in all mice by 9 weeks of age

cellular
• increase in the number of chromosomal aberrations in tumor cells from G3/4 mice compared to G0 mice
• increased length in prostate tumor cells compared to G3/4 mice homozygous for Terttm1Rdp, Ptentm1Rdp and Trp53tm1Brn and hemizygous for Tg(Pbsn-cre)4Prb


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory