mortality/aging
neoplasm
• develop human like MALT lymphomas
• tumors involve different extranodal sites including the small intestine, salivary glands, kidneys, lungs, liver, stomach, ocular adnexa, and spleen, but do not affect the lymph nodes
• many mice (17 of 26) have tumors involving more than 1 site
• tumors are comprised of a morphologically heterogeneous lymphoid population, predominantly composed of marginal zone (centrocyte-like) cells mixed with small lymphocytes, scattered large blasts, and plasma cells
|
immune system
• in the bone marrow
|
• moderate accumulation in the peripheral blood and spleen but not in the lymph nodes
|
• in the bone marrow
|
hematopoietic system
• in the bone marrow
|
• moderate accumulation in the peripheral blood and spleen but not in the lymph nodes
|
• in the bone marrow
|
• expansion of Sca1+ Kit+ Lin- cells in the bone marrow
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue | DOID:0050909 |
OMIM:137245 |
J:185590 |