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Phenotypes Associated with This Genotype
Genotype
MGI:5432017
Allelic
Composition
Tg(Ly6e-MALT1)#Isg/0
Genetic
Background
involves: C57BL/6 * CBA
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phenotype observed in females
phenotype observed in males
N normal phenotype

Tg(Ly6e-MALT1)#Isg/0 mice develop extranodal mucosa-associated lymphoid tissue lymphomas

mortality/aging

neoplasm
• develop human like MALT lymphomas
• tumors involve different extranodal sites including the small intestine, salivary glands, kidneys, lungs, liver, stomach, ocular adnexa, and spleen, but do not affect the lymph nodes
• many mice (17 of 26) have tumors involving more than 1 site
• tumors are comprised of a morphologically heterogeneous lymphoid population, predominantly composed of marginal zone (centrocyte-like) cells mixed with small lymphocytes, scattered large blasts, and plasma cells

immune system
• in the bone marrow
• moderate accumulation in the peripheral blood and spleen but not in the lymph nodes
• in the bone marrow

hematopoietic system
• in the bone marrow
• moderate accumulation in the peripheral blood and spleen but not in the lymph nodes
• in the bone marrow
• expansion of Sca1+ Kit+ Lin- cells in the bone marrow


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory