mortality/aging
• die earlier than transgenic mice wild-type for Trp53
|
neoplasm
• develop aggressive lymphomas characterized by a diffuse infiltrate of large B-lymphocytes with nuclei with dispersed chromatin, deeply basophilic cytoplasm and multiple mitotic figures
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
diffuse large B-cell lymphoma | DOID:0050745 | J:185590 |