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Phenotypes Associated with This Genotype
Genotype
MGI:5432018
Allelic
Composition		 Trp53tm1Tyj/Trp53tm1Tyj
Tg(Ly6e-MALT1)#Isg/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ly6e-MALT1)#Isg mutation (0 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Tg(Ly6e-MALT1)#Isg/0 Trp53tm1Tyj/Trp53tm1Tyj mice develop activated B-cell diffuse large-cell lymphoma

mortality/aging
premature death ( J:185590 )
• die earlier than transgenic mice wild-type for Trp53

neoplasm
increased B cell derived lymphoma incidence ( J:185590 )
• develop aggressive lymphomas characterized by a diffuse infiltrate of large B-lymphocytes with nuclei with dispersed chromatin, deeply basophilic cytoplasm and multiple mitotic figures

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
diffuse large B-cell lymphoma DOID:0050745 J:185590

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory