About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5432018
Allelic
Composition
Trp53tm1Tyj/Trp53tm1Tyj
Tg(Ly6e-MALT1)#Isg/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ly6e-MALT1)#Isg mutation (0 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Tg(Ly6e-MALT1)#Isg/0 Trp53tm1Tyj/Trp53tm1Tyj mice develop activated B-cell diffuse large-cell lymphoma

mortality/aging
• die earlier than transgenic mice wild-type for Trp53

neoplasm
• develop aggressive lymphomas characterized by a diffuse infiltrate of large B-lymphocytes with nuclei with dispersed chromatin, deeply basophilic cytoplasm and multiple mitotic figures

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
diffuse large B-cell lymphoma DOID:0050745 J:185590


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory