Phenotypes Associated with This Genotype

Genotype
MGI:5432191

• Allelic Composition: Tg(YAC72)2511Hay/Tg(YAC72)2511Hay
• Genetic Background: FVB/N-Tg(YAC72)2511Hay

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased neuron apoptosis ( J:105728 )

• general increase in stress-induced apoptosis in primary cultures of striatal neurons

• in cultured striatal medium spiny neurons in response to mitochondria stress

increased susceptibility to neuronal excitotoxicity ( J:105728 )

• in cultured striatal medium spiny neurons following exposure to NMDA, the Ca2+ ionophore A23187, or KCl plus the L-type calcium channel agonist FPL 64176

• apoptosis induced by KCl alone is less than in mice homozygous for Tg(YAC128)55Hay

homeostasis/metabolism

increased susceptibility to neuronal excitotoxicity ( J:105728 )

• in cultured striatal medium spiny neurons following exposure to NMDA, the Ca2+ ionophore A23187, or KCl plus the L-type calcium channel agonist FPL 64176

• apoptosis induced by KCl alone is less than in mice homozygous for Tg(YAC128)55Hay

cellular

increased neuron apoptosis ( J:105728 )

• general increase in stress-induced apoptosis in primary cultures of striatal neurons

• in cultured striatal medium spiny neurons in response to mitochondria stress

increased susceptibility to neuronal excitotoxicity ( J:105728 )

• in cultured striatal medium spiny neurons following exposure to NMDA, the Ca2+ ionophore A23187, or KCl plus the L-type calcium channel agonist FPL 64176

• apoptosis induced by KCl alone is less than in mice homozygous for Tg(YAC128)55Hay

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Huntington's disease		DOID:12858	OMIM:143100	J:105728