Phenotypes Associated with This Genotype

Genotype
MGI:5432215

• Allelic Composition: Il10^tm1Cgn/Il10^tm1Cgn; Tg(MUC1)79.24Gend/0
• Genetic Background: B6.Cg-Il10^tm1Cgn Tg(MUC1)79.24Gend

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

rectal prolapse ( J:149347 )

• rectal prolapse is seen at a median time of 11 weeks of age

increased colon adenocarcinoma incidence ( J:149347 )

• 88% of mutants with colonic inflammation exhibit colon tumors; majority of tumors are invasive adenocarcinomas

• mutants exhibit a higher tumor burden (3-4 tumors per colon on average) than single Il10 homozygotes (1 tumor per colon)

• tumors develop as early as 8-12 weeks of age

large intestinal inflammation ( J:149347 )

• mutants develop segmental, patchy colon inflammation with areas of healthy-appearing colon adjacent to areas of severe inflammation

• mutants exhibit higher total colonic inflammation at 5-6 weeks of age than single Il10 homozygotes and show fewer fields of no inflammation

• neutrophils are the dominant cellular infiltrate in the colon which are not seen in the single Il10 homozygote

• mutants develop progressive inflammatory bowel disease much earlier than single Il10 homozygotes

immune system

large intestinal inflammation ( J:149347 )

• mutants develop segmental, patchy colon inflammation with areas of healthy-appearing colon adjacent to areas of severe inflammation

• mutants exhibit higher total colonic inflammation at 5-6 weeks of age than single Il10 homozygotes and show fewer fields of no inflammation

• neutrophils are the dominant cellular infiltrate in the colon which are not seen in the single Il10 homozygote

• mutants develop progressive inflammatory bowel disease much earlier than single Il10 homozygotes

neoplasm

increased colon adenocarcinoma incidence ( J:149347 )

• 88% of mutants with colonic inflammation exhibit colon tumors; majority of tumors are invasive adenocarcinomas

• mutants exhibit a higher tumor burden (3-4 tumors per colon on average) than single Il10 homozygotes (1 tumor per colon)

• tumors develop as early as 8-12 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
colorectal cancer		DOID:9256	OMIM:114500	J:149347
inflammatory bowel disease		DOID:0050589	OMIM:PS266600	J:149347