Phenotypes Associated with This Genotype

Genotype
MGI:5432223

• Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1⁺; Tg(CYP19A1-cre)1Jri/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:186144 )

• mutants die within 6-8 months of age

neoplasm

increased ovary tumor incidence ( J:186144 )

♀ • ovaries exhibit visible precancerous lesions between 4 and 6 weeks of age and develop granulosa cell tumors

increased granulosa cell tumor incidence ( J:186144 )

reproductive system

increased ovary tumor incidence ( J:186144 )

♀ • ovaries exhibit visible precancerous lesions between 4 and 6 weeks of age and develop granulosa cell tumors

increased granulosa cell tumor incidence ( J:186144 )

endocrine/exocrine glands

increased ovary tumor incidence ( J:186144 )

♀ • ovaries exhibit visible precancerous lesions between 4 and 6 weeks of age and develop granulosa cell tumors

increased granulosa cell tumor incidence ( J:186144 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
ovarian cancer		DOID:2394	OMIM:167000 OMIM:607893	J:186144