Phenotypes Associated with This Genotype

Genotype
MGI:5432224

• Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1⁺; Kras^tm4Tyj/Kras⁺; Tg(CYP19A1-cre)1Jri/0
• Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:186144 )

• mutants die within 3.5-5.5 months of age

neoplasm

increased ovary tumor incidence ( J:186144 )

♀ • female mutants exhibit precancerous lesions in the ovaries at between 4 and 5 weeks of age

increased granulosa cell tumor incidence ( J:186144 )

♀ • female mutants develop bilateral granulosa cell tumors by 3 months of age

endocrine/exocrine glands

impaired granulosa cell differentiation ( J:186144 )

♀ • marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked

increased ovary tumor incidence ( J:186144 )

♀ • female mutants exhibit precancerous lesions in the ovaries at between 4 and 5 weeks of age

increased granulosa cell tumor incidence ( J:186144 )

♀ • female mutants develop bilateral granulosa cell tumors by 3 months of age

reproductive system

impaired granulosa cell differentiation ( J:186144 )

♀ • marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked

increased ovary tumor incidence ( J:186144 )

♀ • female mutants exhibit precancerous lesions in the ovaries at between 4 and 5 weeks of age

increased granulosa cell tumor incidence ( J:186144 )

♀ • female mutants develop bilateral granulosa cell tumors by 3 months of age

homeostasis/metabolism

decreased circulating estradiol level ( J:186144 )

♀ • at 6 weeks of age in females

increased circulating follicle stimulating hormone level ( J:186144 )

♀ • at 6 weeks of age in females

increased circulating luteinizing hormone level ( J:186144 )

♀ • at 6 weeks of age in females

decreased circulating progesterone level ( J:186144 )

♀ • at 6 weeks of age in females

cellular

impaired granulosa cell differentiation ( J:186144 )

♀ • marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
granulosa cell tumor		DOID:2999		J:186144
ovarian cancer		DOID:2394	OMIM:167000 OMIM:607893	J:186144