Phenotypes Associated with This Genotype

Genotype
MGI:5432226

• Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1⁺; Pten^tm1Hwu/Pten^tm1Hwu; Tg(CYP19A1-cre)1Jri/0
• Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased tumor-free survival time ( J:186144 )

• all mutants die within 2-3 months of age due to tumor burden

neoplasm

increased ovary tumor incidence ( J:186144 )

♀ • mutants exhibit precancerous lesions in the ovaries by 3 weeks of age

increased granulosa cell tumor incidence ( J:186144 )

♀ • mutants develop large granulosa cell tumors by 6-8 weeks of age

endocrine/exocrine glands

decreased granulosa cell apoptosis ( J:186144 )

♀ • granulosa cell apoptosis is decreased in the ovaries at 5-6 weeks of age

impaired granulosa cell differentiation ( J:186144 )

♀ • marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked

increased granulosa cell proliferation ( J:186144 )

♀ • granulosa cell proliferation is increased in the ovaries at 5-6 weeks of age

increased ovary tumor incidence ( J:186144 )

♀ • mutants exhibit precancerous lesions in the ovaries by 3 weeks of age

increased granulosa cell tumor incidence ( J:186144 )

♀ • mutants develop large granulosa cell tumors by 6-8 weeks of age

reproductive system

decreased granulosa cell apoptosis ( J:186144 )

♀ • granulosa cell apoptosis is decreased in the ovaries at 5-6 weeks of age

impaired granulosa cell differentiation ( J:186144 )

♀ • marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked

increased granulosa cell proliferation ( J:186144 )

♀ • granulosa cell proliferation is increased in the ovaries at 5-6 weeks of age

increased ovary tumor incidence ( J:186144 )

♀ • mutants exhibit precancerous lesions in the ovaries by 3 weeks of age

increased granulosa cell tumor incidence ( J:186144 )

♀ • mutants develop large granulosa cell tumors by 6-8 weeks of age

homeostasis/metabolism

decreased circulating estradiol level ( J:186144 )

• by 6 weeks of age

increased circulating follicle stimulating hormone level ( J:186144 )

• by 6 weeks of age

increased circulating luteinizing hormone level ( J:186144 )

• by 6 weeks of age

decreased circulating progesterone level ( J:186144 )

• by 6 weeks of age

cellular

decreased granulosa cell apoptosis ( J:186144 )

♀ • granulosa cell apoptosis is decreased in the ovaries at 5-6 weeks of age

impaired granulosa cell differentiation ( J:186144 )

♀ • marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked

increased granulosa cell proliferation ( J:186144 )

♀ • granulosa cell proliferation is increased in the ovaries at 5-6 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
granulosa cell tumor		DOID:2999		J:186144
ovarian cancer		DOID:2394	OMIM:167000 OMIM:607893	J:186144