Phenotypes Associated with This Genotype

Genotype
MGI:5432228

• Allelic Composition: Amhr2^tm3(cre)Bhr/Amhr2⁺; Ctnnb1^tm1Mmt/Ctnnb1⁺
• Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased granulosa cell tumor incidence ( J:186144 )

♀ • female mutants develop granulosa cell tumors by 6 months of age

seminiferous tubule degeneration ( J:186144 )

♂ • seminiferous tubule degeneration is seen by 5 weeks of age

testicular atrophy ( J:186144 )

♂ • progressive loss of spermatogenesis and testicular atrophy with reduced testis size

increased testis tumor incidence ( J:186144 )

♂ • male mutants develop granulosa cell tumors of the testis by 9-13 weeks of age

reproductive system

increased granulosa cell tumor incidence ( J:186144 )

♀ • female mutants develop granulosa cell tumors by 6 months of age

seminiferous tubule degeneration ( J:186144 )

♂ • seminiferous tubule degeneration is seen by 5 weeks of age

testicular atrophy ( J:186144 )

♂ • progressive loss of spermatogenesis and testicular atrophy with reduced testis size

increased testis tumor incidence ( J:186144 )

♂ • male mutants develop granulosa cell tumors of the testis by 9-13 weeks of age

male infertility ( J:186144 )

♂

neoplasm

increased granulosa cell tumor incidence ( J:186144 )

♀ • female mutants develop granulosa cell tumors by 6 months of age

increased testis tumor incidence ( J:186144 )

♂ • male mutants develop granulosa cell tumors of the testis by 9-13 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
granulosa cell tumor		DOID:2999		J:186144
ovarian cancer		DOID:2394	OMIM:167000 OMIM:607893	J:186144